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Compound Summary

General Compound Information

4-methoxyphenol

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Description

P-methoxyphenol is a member of phenols and a member of methoxybenzenes. It has a role as a metabolite.

Synonyms

4-Methoxyphenol; Mequinol; 150-76-5; 4-Hydroxyanisole; p-Hydroxyanisole;

p-Methoxyphenol;HYDROQUINONE MONOMETHYL ETHER;Phenol, 4-methoxy-;Leucobasal;MEHQ;Leucodine B;Mechinolum;P-Guaiacol;Hydroquinone methyl ether;Novo-Dermoquinona;HQMME;p-Hydroxymethoxybenzene;1-Hydroxy-4-methoxybenzene;para-methoxyphenol;Monomethyl ether hydroquinone;4-Methoxy-phenol;PMF (antioxidant);Phenol, p-methoxy-;USAF AN-7;Mono methyl ether hydroquinone;NSC 4960;MFCD00002332;BMS 181158;BMS-181158;DTXSID4020828;NSC-4960;6HT8U7K3AM;CHEBI:69441;NSC4960;Mequinol (INN);NCGC00091390-02;MEQUINOL [INN];DTXCID60828;Mechinolo [DCIT];Mequinolum;Mechinolo;Mequinolum [INN-Latin];CAS-150-76-5;CCRIS 5531;HSDB 4258;EINECS 205-769-8;UNII-6HT8U7K3AM;Mequinol [USAN:INN:DCF];4methoxyphenol;paramethoxyphenol;AI3-00841;p- methoxyphenol;p-methoxy phenol;p-methoxy-phenol;4-methoxy phenol;Eastman HQMME;4-(methoxy)phenol;4HA;4KS;para- hydroxyanisole;4-(methyloxy)phenol;HQME;MEQUINOL [HSDB];MEQUINOL [USAN];Mequinol (USAN/INN);Mequinol, INN, USAN;MEQUINOL [VANDF];PHENOL,4-METHOXY;hydroxyquinone methyl ether;MEQUINOL [MART.];hydroquinone monomethylether;CHEMBL544;MEQUINOL [WHO-DD];EC 205-769-8;NCIMech_000709;WLN: QR DO1;SCHEMBL21009;hydroquinone mono methyl ether;MLS002454409;MEQUINOL [ORANGE BOOK];GTPL6827;ZINC1684;P-HYDROXYANISOLE [INCI];SOLAGE COMPONENT MEQUINOL;SCHEMBL12015251;BDBM36295;HMS2270F04;HMS3264P13;HMS3652O08;Pharmakon1600-00212037;MEQUINOL COMPONENT OF SOLAGE;4-Methoxyphenol, analytical standard;Tox21_111125;Tox21_202367;Tox21_302876;CCG-35855;NSC760357;STL199145;AKOS000119852;Tox21_111125_1;AC-3292;AM10685;CS-W019963;DB09516;NSC-760357;PS-3375;SB40551;4-Methoxyphenol, ReagentPlus(R), 99%;NCGC00091390-01;NCGC00091390-03;NCGC00091390-04;NCGC00256552-01;NCGC00259916-01;BP-23487;HQMME; HYDROXYQUINONE METHYL ETHER;HY-30270;NCI60_004190;SMR001252253;DB-003965;FT-0618865;M0123;S4077;SW219760-1;4-Methoxyphenol, purum, >=98.0% (HPLC);EN300-19649;4-Methoxyphenol, SAJ first grade, >=97.0%;D04926;P17835;AB00641905_06;AB00641905_07;A809071;SR-01000865565;Q-200491;Q2862455;SR-01000865565-2;BRD-K45216060-001-06-8;F9995-1658;Z104474598;4-Methoxybenzyl S-(4,6-dimethylpyrimidin-2-yl)thiocarbonate;

FlavorDB ID

3126

PUBCHEM ID

Molecular Weight

124.14 Molecular Formula

C7H8O2

Openeye Can Smiles

COC1=CC=C(C=C1)O

IUPAC Inchikey

NWVVVBRKAWDGAB-UHFFFAOYSA-N

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Toxicity Summary
Link to the Distributed Structure-Searchable Toxicity (DSSTox) Database
If a mequinol and tretinoin combination topical product is applied excessively, some potential adverse effects like marked redness, peeling of skin, discomfort, discoloration, or hypopigmentation may occur [FDA Label]. Such products are not indicated for oral ingestion [FDA Label]. MSDS data reports that chronic exposure to a dose of 25 UMOL/L in humans can result in mutagenic effects like DNA inhibition in lymphocytes [MSDS].
Source: DrugBank or Hazardous Substances Data Bank (HSDB)

EFSA's chemical Hazards Database : OpenFoodTox
This compound is found in OpenFoodTox with the name: 4-Methoxyphenol

Reference point : Defined point on an experimental dose–response relationship for the critical effect. This term is synonymous to Point of departure (USA). Reference points include the lowest or no observed adverse effect level (LOAEL/NOAEL) or benchmark dose lower confidence limit (BDML), used to derive a reference value or Margin of Exposure in human and animal health risk assessment. In the ecological area, these include lethal dose (LD50), effect concentration (EC5/ECx), no (adverse) effect concentration/dose (NOEC/NOAEC/NOAED), no (adverse) effect level (NEL/NOAEL), hazard concentration (HC5/HCx) derived from a Species Sensitivity Distributions (SSD) for the ecosystem (EFSA Scientific Committee,2018). Citation: DOI 10.5281/zenodo.4740174

Reference point information of this compound is not available!

Reference Value

Reference Value : The estimated maximum dose (on a body mass basis) or the concentration of an agent to which an individual may be exposed over a specified period without appreciable risk. Reference values are established by applying an uncertainty factor to the reference point. Examples of reference values in human health include acceptable daily intake (ADI) for food and feed additives, and pesticides, tolerable upper intake levels (UL) for vitamins and minerals, and tolerable daily intake (TDI) for contaminants and food contact materials. For acute effects and operators, the acute reference dose (ARfD) and the acceptable operator exposure level (AOEL). In animal health and the ecological area, these include safe feed concentrations and the Predicted no effect concentration (PNEC) respectively (EFSA Scientific Committee, 2018). Citation: DOI 10.5281/zenodo.4740174

OUTPUT ID	ASSESSMENT	QUALIFIER	VALUE	UNIT	POPULATION
2236	TTC Cramer Class I	=	30	µg/kg bw/day	Consumers
2084	TTC Cramer Class I	=	30	µg/kg bw/day	Consumers

Genotoxicity

Author	YEAR	OUTPUT ID	Genotoxicity
EFSA AFC	2007	2236	Not determined
EFSA CEF	2011	2084	Not determined

EFSA Outputs

Output ID	Title	DOI	Published
2084	Scientific Opinion on Flavouring Group Evaluation 22, Revision 1 (FGE.22Rev1): Ring-substituted phenolic substances from chemical groups 21 and 25	doi:10.2903/j.efsa.2011.1990	02May2011
2236	Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) on a request from the Commission related to Flavouring Group Evaluation 22: Ring-substituted phenolic substances from chemical groups 21 and 25 (Commission Regulation (EC) No 1565/2000 of 18 July 2000)	doi:10.2903/j.efsa.2007.393	04May2007

Receptors

Receptor	REFERENCE	EC50 [µM]	Effective Concentration [µM]
TAS2R14	details	Activated

Consensus Spectra

Spectrum Type	Spectrum View	Description	Polarity
Experimental GCMS	view	GCMS	positive

Content

Compound Summary

4-methoxyphenol

Description

P-methoxyphenol is a member of phenols and a member of methoxybenzenes. It has a role as a metabolite.

Synonyms

4-Methoxyphenol; Mequinol; 150-76-5; 4-Hydroxyanisole; p-Hydroxyanisole;

FlavorDB ID

3126

PUBCHEM ID

9015

Molecular Weight

124.14

Molecular Formula

C7H8O2

Openeye Can Smiles

COC1=CC=C(C=C1)O

IUPAC Inchikey

NWVVVBRKAWDGAB-UHFFFAOYSA-N

Network

Shown in network

Similarity

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Content

Compound Summary

4-methoxyphenol

Description

P-methoxyphenol is a member of phenols and a member of methoxybenzenes. It has a role as a metabolite.

Synonyms

4-Methoxyphenol; Mequinol; 150-76-5; 4-Hydroxyanisole; p-Hydroxyanisole;

FlavorDB ID

3126

PUBCHEM ID

9015

Molecular Weight

124.14

Molecular Formula

C7H8O2

Openeye Can Smiles

COC1=CC=C(C=C1)O

IUPAC Inchikey

NWVVVBRKAWDGAB-UHFFFAOYSA-N

Network

Shown in network

Similarity

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OpenFoodTox: component 4-Methoxyphenol

Reference Details

GC-MS Spectrum